Name the common precursor of eumelanin and phaeomelanin, produced by the action of tyrosinase on tyrosine.

Name the common precursor of eumelanin and phaeomelanin, produced by the action
of tyrosinase on tyrosine.

1. List two (2) molecular components of desmosomes. (1 mark)
2. Name the cytoskeletal filament type present in adherens junctions. (1 mark)
3. Name the common precursor of eumelanin and phaeomelanin, produced by the action
of tyrosinase on tyrosine. (1 mark)
4. Name the main collagen type present in the dermis. (1 mark)
5. Name one (1) major proteoglycan present in the basement membrane. (1 mark)
6. Name one (1) surface molecule that distinguishes canine dermal dendritic cells from
Langerhans cells. (1 mark)
7. Name the site of origin of mast cells. (1 mark)
8. Name the location within hair follicles of normal Beagle dogs where fibroblast growth
factor 18 is most commonly found. (1 mark)
9. Name a constituent characteristically found in human sebum that is a marker to
distinguish sebaceous-derived lipids from keratinocyte-derived lipids. (1 mark)
Section A continued over page
Veterinary Dermatology Paper 1 Page 3 of 9
10. Name the two (2) cellular layers in the secretory coils of atrichial sweat glands.
(1 mark)
11. Name the cytokine produced by keratinocytes that is the major chemoattractant for
canine neutrophils. (1 mark)
12. State the key structural difference between antigens recognised by antibodies on the
surface of B lymphocytes versus T-cell receptors. (1 mark)
13. Name the key difference in the process of presentation of a peptide to T-cells that
results in anergy rather than activation. (1 mark)
14. Name two (2) endothelial derived mediators responsible for histamine induced
urticaria. (1 mark)
15. Name three (3) phenotypic markers which collectively identify T regulatory cells.
(1 mark)
16. Name two (2) tight junction proteins known to have decreased expression in atopic
dermatitis in Beagle dogs. (1 mark)
17. Name two (2) cell types proposed to be antigen-presenting cells in the elicitation
phase of allergic contact dermatitis. (1 mark)
18. List one (1) major and one (1) minor antibody isotypes involved in the pathogenesis
of canine pemphigus foliaceus. (1 mark)
19. Name the antibody type which is not involved in the pathogenesis of canine
pemphigus foliaceus. (1 mark)
20. Name the primary cell type including two (2) surface markers currently considered to
play a role in the pathogenesis of alopecia areata in horses. (1 mark)
Section A continued over page
Veterinary Dermatology Paper 1 Page 4 of 9
21. List three (3) of the saprophytic fungal species most commonly isolated from normal
skin and/or haircoats in both cats and dogs. (1 mark)
22. Name the fungal pathogen associated molecular pattern (PAMP) that is recognised by
Dectin-1. (1 mark)
23. List two (2) pro-inflammatory cytokines produced by feline neutrophils following
exposure to Microsporum canis. (1 mark)
24. List two (2) pattern recognition receptors (PRRs) which have increased expression in
feline neutrophils following exposure to Microsporum canis. (1 mark)
25. List two (2) virulence factors that have been linked with Malassezia pachydermatis.
(1 mark)
26. Name the form of thyroid hormone that is the major metabolically active form in
dogs. (1 mark)
27. Name the region of the adrenal gland that is responsible for secretion of
glucocorticoids. (1 mark)
28. Name the cellular location of the glucocorticoid receptor responsible for the genomic
effects of glucocorticoids. (1 mark)
29. Name the enzyme responsible for the conversion of testosterone into
dihydrotestosterone. (1 mark)
30. Name two (2) amino acids documented to be reduced by more than 50% in the
plasma of Shih Tsu dogs with hepatocutaneous syndrome. (1 mark)

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